Outer Membrane Porins Contribute to Antimicrobial Resistance in Gram-Negative Bacteria

Gram-negative bacteria depend on their cell membranes for survival and environmental adaptation. They contain two membranes, one of which is the outer membrane (OM), home to several different proteins (Omps). One class important Omps porins, mediate inflow nutrients antimicrobial drugs. The microorganism’s sensitivity antibiotics, are predominantly targeted at internal sites, greatly influenced by permeability characteristics porins. In this review, properties interactions five common OmpA, OmpC, OmpF, OmpW, OmpX, in connection porin-mediated outlined. Meanwhile, review also highlighted discovered regulatory identified molecular mechanisms antibiotic penetration through Taken together, uncovering porins’ functional will pave way investigate effective agents or approaches that use porins as targets get rid resistant gram-negative bacteria.